Basic information of drug: DB01297
| Drug id | DB01297 |
| Drug name | Practolol |
| Description | A beta-adrenergic antagonist that has been used in the emergency treatment of cardiac arrhythmias. |
| State | solid |
| Cas number | 6673-35-4 |
| Synonyms | (±)-practolol 1-(4-acetamidophenoxy)-3-isopropylamino-2-propanol 4'-(2-hydroxy-3-(isopropylamino)propoxy)acetanilide N-(4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)acetamide Practolol Practololo |
| Sequences | None |
| Indication | Used in the emergency treatment of cardiac arrhythmias. |
| Pharmacodynamics | Practolol is a beta-adrenergic receptor antagonist that has been used in the emergency treatment of cardiac arrhythmias. Beta blockers inhibit normal epinephrine-mediated sympathetic actions, but have minimal effect on resting subjects. That is, they reduce the effect of excitement/physical exertio... |
| Mechanism of action | Like other beta-adrenergic antagonists, practolol competes with adrenergic neurotransmitters such as catecholamines for binding at sympathetic receptor sites. Like propranolol and timolol, practolol binds at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting the effects... |
| Metabolism | None |
| Toxicity | Symptoms of overdose include abdominal irritation, central nervous system depression, coma, extremely slow heartbeat, heart failure, lethargy, low blood pressure, and wheezing. |